How do you build an entire creative ecosystem? And what does it take to empower storytellers at scale?
In this episode, Alex speaks with Emmy-nominated producer, writer, doctor and serial entrepreneur Mehret Mandefro, a visionary voice at the intersection of storytelling, healing and creative innovation. As co-founder and MD of Realness Institute, Mehret has spent years strengthening Africa’s media landscape through training, mentorship and systemic infrastructure-building.
She shares her remarkable journey from medicine to media, the origins of her “audiovisual medicine” artistic practice, and the powerful lessons learned from pioneering television in Ethiopia and developing talent across the continent.
In a wide ranging conversation, Mehret also dives into:
• Why creative infrastructure is the missing piece in global storytelling
• How Realness Institute nurtures and de-risks new creative voices
• The urgent need for producers to think like entrepreneurs
• The role of technology and AI in elevating human stories
• Why Africa is central to the future of film
This is a conversation about creativity, systems change and the responsibility we all share in shaping the future of screen storytelling.
About Mehret Mandefro
Mehret Mandefro is an Emmy-nominated producer, writer, and entrepreneur working at the intersection of culture, commerce, and social impact. A former physician turned storyteller, she has dedicated her career to transforming how stories are made—and who gets to tell them. Born in Ethiopia and raised in America, Mehret is a transnational force in global media who has built several groundbreaking enterprises, including Truth Aid Media in New York, Kana TV in Addis Ababa, and the Realness Institute in Cape Town, a nonprofit dedicated to training and mentoring writers, producers, and directors across Africa and the diaspora. Her award-winning film and television work bridges documentary and fiction, revealing hidden truths across the human experience. Her credits include How It Feels to Be Free (American Masters), Sweetness in the Belly (Amazon), Difret (Netflix), The Cost of Inheritance (PBS), Little White Lie (PBS), and Ethiopia’s first teen drama, Yegna. Recognized on Variety’s list of the most impactful women in global entertainment, Mehret is a member of the Academy of Motion Picture Arts and Sciences and is currently building the African Film and Media Arts Collective with artist Julie Mehretu with the support of BMW. Mehret has a BA in Anthropology from Harvard University, an MD from Harvard Medical School, a MSc in Public Health from the London School of Hygiene and Tropical Medicine as a Fulbright Scholar, and a PhD in Cultural Anthropology from Temple University.